Vitiligo is a skin disease due to the disappearance of melanin, the natural pigment for the color of the skin. Main symptom is “white ivory” discolouration of the skin.

Treatment includes corticosteroid therapy, immunomodulatory and skin graft.


Causes: The exact causes of vitiligo are unclear. 

Several factors may contribute, such as autoimmune disorders.

Vitiligo is not contagious.

It can appear at any age, but studies suggest that it is more likely to start around the age of 20.

BIONACRE® is efficient to mitigate the cutaneous manifestations caused by VITILIGO


Easy to use: Topic

No side effects

Really efficient



Psoriasis is a chronic inflammatory skin disease primarily causing scaling and inflammation of skin, but it can also induce other systemic effects and adverse consequences for a patient's overall health. 

It is characterized by sharply demarcated, scaly, red skin lesions most often on the elbows, knees, scalps, hands and feet. It occurs when the body’s immune system sends out faulty signals that speed up the growth cycle of skin cells. Plaques appear in cycles known as flares, and can be triggered by the bacterial or the viral infections, stress, medication and smoking. It is an autoimmune disease.

Psoriasis is considered to be one of the most prevalent autoimmune diseases caused by the inappropriate activation of the cellular immune system, triggering the new skin cells to generate at an alarming rate. Scientists have been unable to find out the exact causes of the psoriasis.

MEGA BioPharma R&D works allowed to show and confirm several of the amazing properties of BIONACRE®, in particularits capacity of healing and skin repair through the regulation and turnover of keratinocytes and the production of collagens.





Less scale

Reduction of scratching

Less inflammation




Easy to use (topic, no injection)

Less social impact

Reduced healthcare cost

Burn Wounds


Burn wounds treated with BIONACRE® 

BIONACRE® components inhibit the production of inflammatory factors and stimulate the local tissue and cell immunity factors. Through its anti-biomimetic properties, BIONACRE® also controls the microbial proliferation, reduces the healing time and allows the heat sedation by inhibitingthe effects of bradykinin.


Example of a patient treated with BIONACRE® cream for burning wounds.


BIONACRE® is able to treat deep 2nd degree burns.




Bedsore treatment with BIONACRE® showing the wound after 12 days.

New revascularization caused by the growth factors properties of BIONACRE®

Restauration of skin integument through the fibroblast proliferation and increased production of collagen.














• BIONACRE® topic use to prevent the development of keloidal scars.

Bionacre® archives brulures (Burn wound) Hopital Makati Philippines



AdobeStock_38665053 SERINGUE

Bionacre® FILLER


BIONACRE®filler is a volumizing complex based on BIONACRE® biomaterial  for fibroblast proliferation regeneration and collagen production.

A better behavior

A really natural aspect

A longer term efficiency 

HIGHEST Safety for a HIGHER Performance


Based on literature review, the NACRE by itself does not raise toxicological concerns.

In order to demonstrate the full BIOCOMPATIBILITY of BIONACRE, BIOLOGICAL studies are conducted by product, according to the regulatory requirements, e.g; ISO 10993-serie such as cytotoxicity, genotoxicity, acute systemic toxicity, hemocompatibility, etc...


QUALITY CONTROLis applied during the whole process chain:

Since controlled sourcing shell selection, bases on detailed specifications

In each step of the manufacturing process

Until the final production and packaging of the devices (including Gamma sterilization)


SPECIFIC PATENTED TREATMENTS are applied in order to boost some physical properties and reinforce the natural efficacy of the biomaterial

Mega Bio Pharma®