Vitiligo is a condition in which skin loses melanin, the pigment that determines the color of skin, hair and eyes. Symptoms include premature whitening or graying of the hair on scalp, eyelashes, eyebrows or beard, loss of color in the tissues that line the inside of mouth and loss of or change in color of the inner layer of eye. Treatment includes corticosteroid therapy, immunomodulatory and surgery. 

Causes: The exact causes of vitiligo are unclear. A number of factors may contribute.

These include an autoimmune disorder, in which the immune system becomes overactive and destroys the melanocytes a genetic oxidative stress imbalance, a stressful event , harm to the skin due to a critical sunburn or cut , exposure to some chemicals, a neural cause, heredity, as it may run in families, a virus… 

Vitiligo is not contagious. One person cannot catch it from another. 

It can appear at any age, but studies suggest that it is more likely to start around the age of 20 years Vitiligo is an orphan disease


BIONACRE® is efficient to erase the skin eruptions caused by VITILIGO


Easy to use: Topic

No side effects

Really efficient



Psoriasis is a chronic inflammatory skin disease primarily causing scaling and inflammation of skin, but it can also result in systemic inflammation and adverse consequences for a patient's overall health. 

It is characterized by sharply demarcated, scaly, red skin lesions most often on the elbows, knees, scalps, hands and feet. It occurs when the body’s immune system sends out faulty signals that speed up the growth cycle of skin cells. Plaques appear in cycles known as flares, and can be triggered by the bacterial or the viral infections, stress, medication and smoking. It is an autoimmune disease.

Psoriasis is considered to be one of the most prevalent autoimmune diseases caused by the inappropriate activation of the cellular immune system, triggering the new skin cells to generate at an alarming rate. Scientists have been unable to find out the exact causes of the psoriasis.

MEGA BioPharma R&D works allowed to show and confirm several of the amazing properties of BIONACRE, in particular its capacity to repair several types of tissues (bone, soft tissues) and place itself under the local systemic regulation of the receiver site, as if it was “biomimetic:




Less stress irritation

No corticoids inside

Less social cost 

Quickly efficient




Comfort for patients as less irritation

Reduction of healthcare costs (no addiction to corticoids)

Easy to use (topic, no injection)

Will change patient social life

Burning Wounds


Burning wounds treated with Bionacre® 

BIONACRE® components inhibit the production of inflammatory factors and stimulate the local tissue and cell immunity factors. Through its anti-biomimetic properties, BIONACRE® also controls the microbial proliferation, reduces the healing time and allows the heat sedation by inhibiting the inflammatory markers such as bradykinin.


Example of a patient treated with BIONACRE® cream for burning wounds.


BIONACRE® is able to treat deep 2nd degree burns.




Bedsore treatment with BIONACRE® showing the wound after 12 days.

New revascularization caused by the growth factors properties of BIONACRE®

Restauration of skin integument through the fibroblast proliferation and increased production of collagen.














• BIONACRE® topic use to prevent the development of keloidal scars.

Bionacre® archives brulures (Burn wound) Hopital Makati Philippines



AdobeStock_38665053 SERINGUE

Bionacre® FILLER



Bionacre® filler is a combination of Bionacre Biomaterial at nano size and a gel for fibroblast regeneration

A better behavior

A really natural aspect

A longer term efficiency 

HIGHEST Safety for a HIGHER Performance


Based on literature review, the NACRE by itself does not raise toxicological concerns.

In order to demonstrate the full BIOCOMPATIBILITY of BIONACRE, BIOLOGICAL studies are conducted by product, according to the regulatory requirements, e.g; ISO 10993-serie such as cytotoxicity, genotoxicity, acute systemic toxicity, hemocompatibility, etc...


QUALITY CONTROLis applied during the whole process chain:

Since controlled sourcing shell selection, bases on detailed specifications

In each step of the manufacturing process

Until the final production and packaging of the devices (including Gamma sterilization)


SPECIFIC PATENTED TREATMENTS are applied in order to boost some physical properties and reinforce the natural efficacy of the biomaterial

Mega Bio Pharma®